Preheat oven to 350°F. Grease 12 muffin tins or line with paper muffin liners; set aside.
In a large bowl, stir together the flour, bran, high fiber cereal, brown sugar, baking powder, baking soda, salt, flaxseed meal, spices and brewer's yeast.
In a separate bowl, beat pumpkin puree, vegetable oil and eggs. Mix until smooth. Stir in cranberries. Scoop batter into prepared muffin tins.
Bake in preheated oven for 20 - 25 minutes, until a toothpick inserted into the center of the muffin comes out clean.